HPV

The status of human papillomavirus infections in women in Yunnan in the south of China and their correlation with grade of cervical intraepithelial ...

Single subtype infection and multiple subtype infection have different impacts on CIN. Kim et al 20 compared the HPV genotypes of 236 patients with a multiple subtype infection and 180 patients with a single subtype infection, and they found that the correlation between multiple subtype infections and HSIL was closer than that between a single subtype infection and HSIL. The infections were also seen to last longer in patients with multiple subtype infections than in patients with a single subtype infection. The three subtypes of HR-HPV with the highest infection rate were HPV16, HPV52 and HPV58. HPV43 is the main subtype of LR-HPV. There was no correlation between ethnicity and single or multiple infections in different CIN groups. The main HR-HPV subtypes were 52 (25.3%), 58 (16.1%) and 16 (16.1%) in the LSIL group, and 16 (37.8%), 58 (15.4%), and 52 (11.2%) in the HSIL group. In the LSIL group, there were 39 cases of single infection and 15 cases of multiple infection in han nationality, 19 cases of single infection and 6 cases of multiple infection in minority nationality, χ2= 0.0063, P > 0.05, the difference was not statistically significant. The main LR-HPV subtypes were 43 (23.8%), 42 (19.0%), and 40 (4.8%) in the LSIL group, and 43 (29.4%), 81 (29.4%), and 11 (17.6%) in the HSIL group. This is related to the different susceptibility and clearance rates of different types of HPV in different regions, different nationalities and different physical hosts. Single and multiple infection rates of different ages in LSIL group showed no significant difference (X2 = 2.797, P = 0.258). There was also no significant difference in single and multiple infection rates of different ages in HSIL group (X2 = 5.037, P = 0.081) ( Table 2). In the LSIL group, there were 27 patients (34%) with a single subtype infection in the age range from 30 to 45 years, which was the age group with the highest proportion of single-type infections, and in the HSIL group, there were 83 patients (41%) with a single subtype infection in the age range from 30 to 45 years old, which was also the main single subtype infection age group. In HISL group, there were 131 cases of single infection and 41 cases of multiple infection in han nationality, 22 cases of single infection and 8 cases of multiple infection in minority nationality (χ2=0.0105, P>0.05). It showed that there was no significant difference between ethnic group and single or multiple infection in different CIN groups ( Table 4). However, it should be noted that two ethnic HSIL patients had a single LR-HPV infection. Twelve percent of HSIL patients were <30 years old, and there were 60 patients aged 30–45 years in the HSIL group, accounting for 58% of the group, and this was the age group with a high incidence. Immunohistochemical P16 expression was block-positive reactivity in HSIL patients ( Figure 2), Ki67 index >30% ( Figure 3). Morphological LSIL patients showed negative or mottled expression of P16 and Ki67 index <30%. 2, 3 Human papillomavirus (HPV) infections are known to be closely related to cervical precancerous lesions and cervical cancer, and the main cause of cervical cancer is a persistent infection of high-risk HPV (HR-HPV). 4, 5 Cervical intraepithelial neoplasia (CIN) is a precancerous disease.